2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-133175
    Biotin-PEG7-azide 1334172-75-6 99.87%
    Biotin-PEG7-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTAC. Biotin-PEG7-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Biotin-PEG7-azide
  • HY-140607
    m-PEG3-Sulfone-PEG3 1919045-00-3
    m-PEG3-Sulfone-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG3-Sulfone-PEG3
  • HY-140554
    N-Boc-N-bis(C2-PEG1-azide) 2100306-79-2
    N-Boc-N-bis(C2-PEG1-azide) is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. N-Boc-N-bis(C2-PEG1-azide) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N-Boc-N-bis(C2-PEG1-azide)
  • HY-138765
    Propargyl-PEG7-amine
    Propargyl-PEG7-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG7-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG7-amine
  • HY-141102
    Fmoc-PEG24-NHS ester
    Fmoc-PEG24-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-PEG24-NHS ester
  • HY-116025
    APN-C3-PEG4-alkyne 2183440-36-8
    APN-C3-PEG4-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. APN-C3-PEG4-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    APN-C3-PEG4-alkyne
  • HY-140475
    Boc-NH-PEG36-CH2CH2COOH
    Boc-NH-PEG36-CH2CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-PEG36-CH2CH2COOH
  • HY-138530
    Thiol-PEG4-amide-NH2
    Thiol-PEG4-amide-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Thiol-PEG4-amide-NH2
  • HY-130909
    Propargyl-PEG25-acid
    Propargyl-PEG25-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG25-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG25-acid
  • HY-159572
    NH2-C5-Azacyclohexane-N-Boc
    NH2-C5-Azacyclohexane-N-Boc is a PROTAC linker. NH2-C5-Azacyclohexane-N-Boc can be used in synthesis XD2-149 (HY-159570).
    NH2-C5-Azacyclohexane-N-Boc
  • HY-122413
    m-PEG7-NHS ester 874208-92-1
    m-PEG7-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    m-PEG7-NHS ester
  • HY-141201
    m-PEG3-aminooxy-Boc 1835759-87-9
    m-PEG3-aminooxy-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG3-aminooxy-Boc
  • HY-132011
    Benzyl-PEG13-THP
    Benzyl-PEG13-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Benzyl-PEG13-THP
  • HY-140433
    Boc-Aminooxy-PEG4-azide 2100306-64-5
    Boc-Aminooxy-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Boc-Aminooxy-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Boc-Aminooxy-PEG4-azide
  • HY-138460
    Propargyl-PEG10-alcohol 2378150-09-3
    Propargyl-PEG10-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG10-alcohol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG10-alcohol
  • HY-W872575A
    (R)-TCO4-PEG3-Maleimide
    TCO4-PEG3-Maleimide is a PROTAC linker and belongs to the PEG class. TCO4-PEG3-Maleimide contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, or "mercapto-acrylamide" reactions.
    (R)-TCO4-PEG3-Maleimide
  • HY-141094
    Pyrene-PEG5-biotin
    Pyrene-PEG5-biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Pyrene-PEG5-biotin
  • HY-159018
    Alkyne-C6-OMs 228403-45-0
    Alkyne-C6-OMs is a PROTAC linker that can be used in the synthesis of PROTACs.
    Alkyne-C6-OMs
  • HY-138326
    Bis-PEG18-Boc
    Bis-PEG18-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bis-PEG18-Boc
  • HY-140531
    N-(Biotin-PEG4)-N-bis(PEG4-acid) 2112731-48-1
    N-(Biotin-PEG4)-N-bis(PEG4-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    N-(Biotin-PEG4)-N-bis(PEG4-acid)
PROTAC Linkers Isoform Comparison

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